What is trimetazidine used for?

Trimetazidine is a medicine used to prevent angina attacks, which are sudden pains to the chest, jaw and back brought on by physical effort, due to reduced blood flow to the heart. Angina is commonly associated with a narrowing of the blood vessels that supply the heart, called the coronary arteries.

What is the benefit of taking trimetazidine?

Trimetazidine (TMZ) is a medication used to treat heart-related conditions like angina. It helps metabolize fatty acids, which helps your body use oxygen. The drug allows for more blood flow to your heart and limits quick changes in your blood pressure. This can help lessen chest pain from blocked blood vessels.

Why is trimetazidine banned?

The drug is currently listed as a “metabolic modulator” and WADA prohibits athletes from using the drug in or out of competition. A shift in how the body uses energy could give athletes an edge in competitions by lessening their altitude fatigue and increasing their cardiovascular fitness (Biomed. Pharmacother.

Does trimetazidine lower blood pressure?

Unlike conventional drugs, trimetazidine exerts no effect on coronary flow, contractility, blood pressure, or heart rate.

How long can you take trimetazidine?

Conclusion: Treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced a functional improvement in patients with dilated cardiomyopathy. Trimetazidine treatment was associated with a significant improvement of left ventricular function and the remodelling process.

Is trimetazidine safe?

Trimetazidine Adverse Drug Reactions

Trimetazidine has been generally very well tolerated in clinical trials and usually only isolated cases of adverse events (ADRs—adverse drug reactions) were observed during trimetazidine treatment (mainly gastrointestinal disturbances, vomiting, nausea) [61].

Is trimetazidine safe to take?

Serious adverse reactions, including Parkinsonian symptoms, involuntary muscle movements, and difficulty walking, have been reported after the long-term use of trimetazidine. Trimetazidine is not approved by the FDA for clinical use in the United States and is not well known as a doping drug in this country.

What foods to avoid if you have angina?

Avoid foods that contain saturated fat and partially hydrogenated or hydrogenated fats. These are unhealthy fats that are often found in fried foods, processed foods, and baked goods. Eat fewer foods that contain cheese, cream, or eggs.

Does trimetazidine lower heart rate?

The dose of trimetazidine does not affect hemodynamic stability, heart rate, blood pressure and speed-pressure multiplication, and it exerts no negative inotropic effect.

What is the side effects of trimetazidine?

Trimetazidine has a significant side effects profile, with the most common adverse reactions being nausea, vomiting, fatigue, dizziness, and myalgia. The drug can induce or increase parkinsonian symptoms: extrapyramidal rigidity, bradykinesia, and tremor.

Is trimetazidine a stimulant?

TMZ, a substance prohibited in competition, is classified in the S6b Specified Stimulant Group. TMZ is used as a well-known cardiologic drug with confirmed biochemical and clinical activity.

What is an angina heart?

Angina is chest pain caused by reduced blood flow to the heart muscles. It's not usually life threatening, but it's a warning sign that you could be at risk of a heart attack or stroke. With treatment and healthy lifestyle changes, it's possible to control angina and reduce the risk of these more serious problems.

What causes angina?

Angina is caused by reduced blood flow to the heart muscle. Blood carries oxygen, which the heart muscle needs to survive. When the heart muscle isn't getting enough oxygen, it causes a condition called ischemia. The most common cause of reduced blood flow to the heart muscle is coronary artery disease (CAD).

Can I take trimetazidine once a day?

Trimetazidine has been shown to reduce angina symptoms in people with stable angina. Usually, trimetazidine is taken twice, or three times, each day. A new altered form of trimetazidine, which can be taken once a day, may improve patient-satisfaction.

What is brand name for trimetazidine?

Trimetazidine is marketed as Vastarel^® in Denmark, France (Biopharma), Greece, Hong Kong, Ireland, Italy (Stroder), Portugal, Singapore and Thailand for the treatment of angina pectoris, vascular eye disorders and vestibular disorders such as vertigo and tinnitus associated with Ménière's disease.

Is trimetazidine a beta blocker?

Despite efficacy being equivalent to that of beta-blockers and calcium antagonists, trimetazidine does not depress cardiac function and, correspondingly, is not contraindicated in any condition. Adverse effects of trimetazidine are mild and infrequent.

Which is the best fruit for heart?

Strawberries, blueberries, blackberries, and raspberries are jam-packed with important nutrients that play a central role in heart health. Berries are also rich in antioxidants like anthocyanins, which protect against the oxidative stress and inflammation that contribute to the development of heart disease ( 9 ).

What is the fastest way to cure angina?

Typically your doctor will prescribe medication and lifestyle changes before they suggest surgery. However, if you have severe angina, you may need to undergo an angioplasty or stenting. The fastest way to treat angina is by getting rest and making lifestyle changes.

Is banana good for angina?

High in potassium, foods like bananas can stop fatal blockages from occurring and inhibit the hardening and narrowing of arteries. Researchers at the University of Alabama discovered the effects after analysing mice who were at risk of heart disease.

What time should I take trimetazidine?

Take Trimetazidine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Take it together with food or immediately after a meal. Try to take it at the same time each day.

Does angina show up on an ECG?

Diagnosing angina

Your doctor can suspect a diagnosis of angina based on your description of your symptoms, when they appear and your risk factors for coronary artery disease. Your doctor will likely first do an electrocardiogram (ECG) to help determine what additional testing is needed to confirm the diagnosis.

Can angina go away?

If it's angina, your symptoms usually ease or go away after a few minutes' rest, or after taking the medicines your doctor or nurse has prescribed for you, such as glyceryl trinitrate medicine (GTN). If you're having a heart attack, your symptoms are less likely to ease or go away after resting or taking medicines.

Can angina be cured?

In other words, increasing the blood flow to the heart will ease symptoms. Unfortunately, there's no magic pill for angina. It cannot be “cured.” But you can find some relief by working with your doctor to find the right combination of lifestyle changes, medications and medical procedures.

Where is angina pain located?

Angina is chest pain or discomfort caused when your heart muscle doesn't get enough oxygen-rich blood. It may feel like pressure or squeezing in your chest. The discomfort also can occur in your shoulders, arms, neck, jaw, abdomen or back. Angina pain may even feel like indigestion.

Can angina be cured naturally?

Clinical evidence has shown that stable angina can be improved with the proper food choices and exercise. Yes, the power is in you. You can help your heart heal by making small and easy healthy lifestyle changes. To improve your angina you may need to do more than the odd sweaty workout or eat the occasional salad.